I'm using version 2.2.2 of the ShrewSoft VPN client on my 64bit Win7 laptop. For some reason, the 'Manage' window doesn't show in this version - which bit me when my VPN details changed. The .pcf configuration files aren't re-read if you edit them and so you have to have access to the 'manage' dialog in order to update your connection - you can't even add a connection without accessing this dialog.
So, the solution for me was actually quite simple -
- try to bring up the 'Manager' dialog (right click the ShreSoft icon in the bottom right of the taskbar and click on 'Manage')
- bring up the task manager (
Ctrl-Shift-Esc
is a handy short-cut for that) - the VPN manager should be present in the "Applications" window - right click this and select 'maximize'